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Indication & Dosage |
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| Precautions |
Alcohol; sedation, dependence, epilepsy, cardiac disease; Elderly, debilitated patients, children. Withdrawal should be gradual. |
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Potentially Life-threatening
Adverse Drug Reactions |
Physical and psychological dependence; withdrawal syndrome; impairs psychomotor performance, more accident-prone; aggression (in predisposed individuals esp in combination with alcohol); sedation, sinus tachycardia, AV/bundle-branch block, postural hypotension, dry mouth, weight/loss gain, constipation, urinary hesitancy/retention, impotence; blurring of vision, exacerbation of glaucoma, liver dysfunction, eosinophilia, leucopaenia, tremors. |
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| Adverse Drug Reactions |
Chlordiazepoxide may rarely cause hypoplastic or haemolytic anaemia. Imipramine rarely causes agranulocytosis. |
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| Interactions |
Chlordiazepoxide: Cimetidine increases serum concentration. Absorption is impaired by Mg trisilicate, morphine, pethidine and atropine. Absorption enhanced by metoclopramide and aluminium hydroxide. Potentiates action of major neuroleptics.
Imipramine: Barbiturates reduce plasma levels thereby reducing antidepressant effect. Cimetidine elevates serum imipramine concentrations and consequently adverse effects. Causes drowsiness and impaired performance in combination with alcohol. |
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